Department of Occupational Diseases, Clinical Immunology and Clinical Pharmacology

Dear students of  group 461 

of Faculty of Dentistry !

Tomorrow 18th FEBRUARY 2025, 

you will have practical classes in the cycle "Clinical pharmacology"

 Classes on will begin at 10.00  a.m. 

Teachers of cycle: 

Professor Victoriia Rodionova (subgroup 1)

https://meet.google.com/zki-ffcz-iyc

Associate professor Valeriia Dmytrychenko (subgroup 2)

https://meet.google.com/zki-ffcz-iyc

Dear students of group 461!!

Topics of reports on clinical pharmacology are given below:

Clinical pharmacology of local anesthetics. Emergency conditions when using local anesthetics:

 Injectable anaesthetic

• • Low potency (short duration)- Procaine, Chloroprocaine

  • Intermediate potency and duration- Lidocaine (Lignocaine), Prilocaine

  • High potency (long duration)- Tetracaine, Bupivacaine, Ropivacaine, Dibucaine

• Surface anaesthetic

  • Soluble- Insoluble, Cocaine, Lidocaine, Tetracaine, Proparacaine

  • Insoluble- Benzocaine,Butylamino- benzoate, Oxethazaine

  • 
    

Emergency conditions when using local anesthetics. 

Clinical pharmacology of anti-inflammatory drugs (nonsteroidal and steroidal): 

Nonsteroidal anti-inflammatory drugs (NSAIDs):

 Non-selective NSAIDs: Diclofenac, Diflunisal, Etodolac, Fenoprofen, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Mefenamic acid, Meloxicam, Nabumetone, Naproxen, Oxaprozin, Piroxicam, Sulindac, Tolmetin

COX-2 Selective NSAIDs: Celecoxib, Rofecoxib, Valdecoxib

Corticosteroids (Glucocorticoids (anti-inflammatory)

Clinical pharmacology of antibacterial, antiviral, etc. drugs (antibiotics, fluoroquinolones, nitroimidazoles, nitrofurans, sulfonamides, etc.):

• PENICILLINS (Penicillin G, Penicillin-VK,  Methicillin Nafcillin Oxacillin, Ampicillin 

• FLUOROQUINOLONES : Ciprofloxacin (Cipro), Levofloxacin (Levaguin), Moxifloxacin (Avelox), Norfloxacin 

•  AMINOGLYCOSIDES : Amikacin, Gentamicin, Kanamycin, Neomycin, Tobramycin 

• CARBAPENEMS:  Ertapenem,  Imienem Meropenem + MONOBACTAMS: Aztreonam  

• Linezolid , Clindamycin 

• MACROLIDES: Azithromycin, Clarithromycin, Dirithromycin, Erythromycin

• CEPHALOSPORINS:

First generation: Cephalothin, Cefazolin (Ancef, Kefzol) , Cephapririn,  Cephalexin (Keflex);

Second Generation: Cefacor Cefotetan (Cefotan) ; 

Third Generation: Ceftriaxone (Rocephin) other;

Fourth Generation: Cefpirome Cefepime; 

Fifth Generation: ceftarolin, ceftabiproli 

Emergency conditions when using medicines.

Clinical pharmacology of antihypertensive drugs:

ACE inhibitors: captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril, benazepril

Angiotensin II receptor antagonists: azilsartan,candesartan, eprosartan,irbesartan,losartan,olmesartan, telmisartan, valsartan,fimasartan

Calcium channel blockers:                                                                                                  dihydropyridines: amlodipine, barnidipine, cilnidipine, clevidipine, felodipine, isradipine, lercanidipine, levamlodipine, nicardipine, nifedipine, nimodipine, nisoldipine, nitrendipine

non-dihydropyridines: diltiazem, verapami

Beta blockers: acebutolol, atenolol, bisoprolol, betaxolol, carteolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, oxprenolol, penbutolol, pindolol, propranolol, timolol, 

Alpha blockers: doxazosin, chlorpromazine, phentolamine, indoramin, phenoxybenzamine, prazosin, terazosin, tolazoline, urapidil

Mixed Alpha + Beta blockers:  bucindolol, carvedilol, labetalol, clonidine (indirectly)

Aldosterone receptor antagonist: eplerenone, spironolactone

Clinical pharmacology of diuretic drugs:

thiazide diuretics (epitizide,hydrochlorothiazide, chlorothiazide, bendroflumethiazide, methyclothiazide,polythiazide),

thiazide-like diuretics (indapamide, chlorthalidone, metolazone, xipamide, clopamide)

loop diuretics (bumetanide, ethacrynic acid, furosemide,torsemide)

potassium-sparing diuretics (amiloride, triamterene, spironolactone, eplerenone)

osmotic diuretics

arbonic anhydrase inhibitors.  

Clinical pharmacology of 

antianginal:

Nitrates:  Short acting (Glyceryl trinitrate (GNT, Nitogycerine) and Long acting (Isosorbide dinitrate, Isosorbide mononitrate, Erythrityl tetranitrate), 

anti ischemic drugs

hypolipidemic drugs (statins, fibrates, bile-acid sequestrants, and nicotinic acid and acipimox)

Clinical pharmacology of drugs that affect the ability of blood to coagulate:

Thrombolytic Drugs

Antiplasmin Agent

Antiplatelet Drugs 

Vitamin K 

Anticoagulants 

Clinical pharmacology of drugs affecting the metabolism of bone tissue, vitamins in dental practice.

Clinical pharmacology of antiallergic drugs:

H-1 Antihistamines

• Diphenhydramine

• Cetirizine

• Chlorpheniramine

• Cyclizine

• Dimenhydrinate (incorporates diphenhydramine and a stimulant compound)

• Doxylamine

• Hydroxyzine

• Meclizine

H-2 Antihistamines

• Cimetidine

• Famotidine (most common H-2 antihistamine that is used in the United States)

• Raniditine (removed from market)

• Nizatidine

• Roxatidine (not available in the USA)

Acute allergic reactions (anaphylactic shock, Quincke's edema, acute urticaria). Emergencies in dental practice. 

Clinical pharmacology of drugs for emergency care. 

                                               Dear students of group 411!!

Since 8 October  2024, 

you will have practical classes in the cycles "Occupational diseases" and "Clinical pharmacology"

 Start of classes since 8 th October at 10.00 a.m.

Teachers of cycle: 

Professor Victoriia Rodionova (subgroup 1 and subgroup 2)

https://meet.google.com/cpx-cnxk-byh 

Since 14 October  2024, 

Teachers of cycle: 

Professor Victoriia Rodionova (subgroup 1)

https://meet.google.com/cpx-cnxk-byh

Associate professor Valeriia Dmytrychenko (subgroup 2)

https://meet.google.com/zki-ffcz-iyc

Dear students of group 411!!

Topics of reports on clinical pharmacology are given below:

DAY 1

Clinical pharmacology of drugs for the treatment of bronchial obstruction syndrome: 

1. Inhaled corticosteroids

• Beclomethasone dipropionate (Qvar®). Budesonide (Pulmicort®). Ciclesonide (Alvesco®). Fluticasone (Arnuity®, Flovent®). Mometasone (Asmanex®).

2. Short-acting bronchodilators

• Albuterol (Proventil HFA®, ProAir®, Ventolin HFA®). Levalbuterol (Xopenex®). Ipratropium (Atrovent®).

3. Long-acting bronchodilators of LAMAs include: 

Aclidinium (Tudorza®). Glycopyrrolate (Seebri®). Tiotropium (Spiriva®). Umeclidinium (Incruse®).

4. Long-acting bronchodilators of LABAs include: Olodaterol (Striverdi®). Salmeterol (Serevent®).Formoterol (Foradil®).Indacaterol (Arcapta®).

5. LABA/LAMA

Glycopyrrolate/formoterol (Bevespi Aerosphere®). Tiotropium/olodaterol (Stiolto®). Indacaterol/glycopyrrolate (Utibron®).Umeclidinium/vilanterol (Anoro®).

6. ICS/LABA

Fluticasone/salmeterol (Advair®).Budesonide/formoterol (Symbicort®).Mometasone/formoterol (Dulera®).Fluticasone/vilanterol (Breo®).

7. ICS/LABA/LAMA 

Fluticasone/umeclidinium/vilanterol (Trelegy®). Budesonide/glycopyrrolate/formoterol (Breztri®).

Clinical pharmacology of anti-inflammatory drugs (nonsteroidal and steroidal): 

Nonsteroidal anti-inflammatory drugs (NSAIDs):

 Non-selective NSAIDs: Diclofenac, Diflunisal, Etodolac, Fenoprofen, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Mefenamic acid, Meloxicam, Nabumetone, Naproxen, Oxaprozin, Piroxicam, Sulindac, Tolmetin

COX-2 Selective NSAIDs: Celecoxib, Rofecoxib, Valdecoxib

Corticosteroids (Glucocorticoids (anti-inflammatory)

Clinical pharmacology of antibacterial, antiviral, etc. drugs (antibiotics, fluoroquinolones, nitroimidazoles, nitrofurans, sulfonamides, etc.):

• PENICILLINS (Penicillin G, Penicillin-VK,  Methicillin Nafcillin Oxacillin, Ampicillin 

• FLUOROQUINOLONES : Ciprofloxacin (Cipro), Levofloxacin (Levaguin), Moxifloxacin (Avelox), Norfloxacin 

•  AMINOGLYCOSIDES : Amikacin, Gentamicin, Kanamycin, Neomycin, Tobramycin 

• CARBAPENEMS:  Ertapenem,  Imienem Meropenem + MONOBACTAMS: Aztreonam  

• Linezolid , Clindamycin 

• MACROLIDES: Azithromycin, Clarithromycin, Dirithromycin, Erythromycin

• CEPHALOSPORINS:

First generation: Cephalothin, Cefazolin (Ancef, Kefzol) , Cephapririn,  Cephalexin (Keflex);

Second Generation: Cefacor Cefotetan (Cefotan) ; 

Third Generation: Ceftriaxone (Rocephin) other;

Fourth Generation: Cefpirome Cefepime; 

Fifth Generation: ceftarolin, ceftabiproli 

DAY 2

Clinical pharmacology of antihypertensive drugs:

ACE inhibitors: captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril, benazepril

Angiotensin II receptor antagonists: azilsartan,candesartan, eprosartan,irbesartan,losartan,olmesartan, telmisartan, valsartan,fimasartan

Calcium channel blockers:                                                                                                  dihydropyridines: amlodipine, barnidipine, cilnidipine, clevidipine, felodipine, isradipine, lercanidipine, levamlodipine, nicardipine, nifedipine, nimodipine, nisoldipine, nitrendipine

non-dihydropyridines: diltiazem, verapami

Beta blockers: acebutolol, atenolol, bisoprolol, betaxolol, carteolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, oxprenolol, penbutolol, pindolol, propranolol, timolol, 

Alpha blockers: doxazosin, chlorpromazine, phentolamine, indoramin, phenoxybenzamine, prazosin, terazosin, tolazoline, urapidil

Mixed Alpha + Beta blockers:  bucindolol, carvedilol, labetalol, clonidine (indirectly)

Aldosterone receptor antagonist: eplerenone, spironolactone

Clinical pharmacology of diuretic drugs:

thiazide diuretics (epitizide,hydrochlorothiazide, chlorothiazide, bendroflumethiazide, methyclothiazide,polythiazide),

thiazide-like diuretics (indapamide, chlorthalidone, metolazone, xipamide, clopamide)

loop diuretics (bumetanide, ethacrynic acid, furosemide,torsemide)

potassium-sparing diuretics (amiloride, triamterene, spironolactone, eplerenone)

osmotic diuretics

arbonic anhydrase inhibitors.  

Clinical pharmacology of 

antianginal:

Nitrates:  Short acting (Glyceryl trinitrate (GNT, Nitogycerine) and Long acting (Isosorbide dinitrate, Isosorbide mononitrate, Erythrityl tetranitrate), 

anti ischemic drugs

hypolipidemic drugs (statins, fibrates, bile-acid sequestrants, and nicotinic acid and acipimox)

Clinical pharmacology of drugs that affect the ability of blood to coagulate:

Thrombolytic Drugs

Antiplasmin Agent

Antiplatelet Drugs 

Vitamin K 

Anticoagulants 

DAY 3

Clinical pharmacology of drugs for the treatment of diseases of the gastrointestinal tract:

ANTACIDS 

H2-RECEPTOR ANTAGONISTS 

PROTON-PUMP INHIBITORS (PPIS)

SUCRALFATE 

PROSTAGLANDIN ANALOGS 

BISMUTH COMPOUNDS  

DRUGS STIMULATING GASTROINTESTINAL MOTILITY 

Clinical pharmacology of drugs for the treatment of diseases of the hepatobiliary system